VJOncology
VJOncology
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Dose-intense 177Lu-PSMA-617 regimen for mCRPC: promising efficacy and manageable toxicity
Scott Tagawa, MD, MS, FACP, Weill Cornell Medical Center, New York, NY, discusses the development and results of a dose-intense regimen using 177Lu-PSMA-617 for progressive metastatic castration-resistant prostate cancer (mCRPC) in the Phase I/II study (NCT03042468). This fractionated dose strategy aims to maintain high levels of radiation in tumors over an extended period to potentially overcome resistance and improve outcomes. In this first dose-escalation study, efficacy results were promising, with an 8.3-month radiographic progression-free survival (rPFS), 17.5-month overall survival (OS), and a 54% PSA response rate without pre-selection for PSMA expression. The regimen showed manageable toxicity, primarily dry mouth, fatigue, and nausea, with few grade 3 or 4 adverse events, suggesting a favorable efficacy-toxicity ratio compared to traditional multi-cycle approaches. This interview took place during the 2024 American Society of Clinical Oncology (ASCO) Meeting in Chicago, IL.
These works are owned by Magdalen Medical Publishing (MMP) and are protected by copyright laws and treaties around the world. All rights are reserved.
Переглядів: 54

Відео

Key findings from Phase I/II Study: fractionated Lu-177 PSMA therapy shows safety and promise
Переглядів 3916 годин тому
Scott Tagawa, MD, MS, FACP, Weill Cornell Medical Center, New York, NY, presented key findings from a Phase I/II study (NCT03042468) on fractionated dose Lutetium-177 (Lu-177) PSMA therapy. The study demonstrated that dose escalation or higher doses of injected radioactivity are safe and effective. Additionally, the fractionated or dose-dense regimen showed promising activity in a PSMA-unselect...
Future potential and challenges of AdAPT-001: evaluating efficacy and exploring new cancer types
Переглядів 3316 годин тому
Anthony Paul Conley, MD, The University of Texas MD Anderson Cancer Center, Houston, TX, discussed the future potential and challenges of AdAPT-001 in cancer therapy. He emphasized the need to evaluate the efficacy signals across various tumors and consider exploring other cancer types. Dr Conley envisions AdAPT-001 as an ideal treatment for patients previously exposed to immunotherapy, aiming ...
Safety and tolerability of AdAPT-001 in Phase II trial: no dose-limiting toxicity observed
Переглядів 2816 годин тому
Anthony Paul Conley, MD, The University of Texas MD Anderson Cancer Center, Houston, TX, shared insights on the safety and tolerability of AdAPT-001 in a multicenter Phase II trial (NCT04673942). Surprisingly, no dose-limiting toxicity or serious adverse events directly related to AdAPT-001 were observed. The most common side effects were mild, with grade one flu-like symptoms resolving within ...
Multicenter Phase II trial evaluates AdAPT-001 for resistant tumors, showing promising efficacy
Переглядів 5516 годин тому
Anthony Paul Conley, MD, The University of Texas MD Anderson Cancer Center, Houston, TX, discusses a multicenter Phase II trial (NCT04673942) evaluating AdAPT-001, an oncolytic adenovirus armed with a "TGF-β trap," with or without a checkpoint inhibitor (CI) in resistant patients, some of whom had previously failed CI therapy. In the study, 36 patients received AdAPT-001, with 25 patients under...
Phase I/II study of AdAPT-001 plus an ICI for patients with immune refractory cancers
Переглядів 2116 годин тому
Anthony Paul Conley, MD, The University of Texas MD Anderson Cancer Center, Houston, TX, discusses a multicenter Phase II trial (NCT04673942) evaluating AdAPT-001, an oncolytic adenovirus armed with a "TGF-β trap," /- a checkpoint inhibitor (CI) in resistant patients, some previously CI-failed. 36 patients received AdAPT-001, with or without a CI, showing manageable adverse events. The combinat...
AdAPT-001: the TGF-β-trap-enhanced oncolytic adenovirus
Переглядів 1716 годин тому
Anthony Paul Conley, MD, The University of Texas MD Anderson Cancer Center, Houston, TX, provides an overview of the mechanism of action AdAPT-001 and the rationale behind combining it with an immune checkpoint inhibitor for patients with immune refractory cancers. This interview took place during the 2024 American Society of Clinical Oncology (ASCO) Meeting in Chicago, IL. These works are owne...
Age-related differences in fertility preservation for premenopausal women with early-stage EC
Переглядів 1919 годин тому
Yukio Suzuki, MD, PhD, Columbia University Irving Medical Center, New York, NY, discusses reasons behind age-related differences in outcomes on long-term survival outcomes for hormonal therapy in premenopausal patients with clinical stage I endometrial cancer. This interview took place during the 2024 American Society of Clinical Oncology (ASCO) Meeting in Chicago, IL. These works are owned by ...
Key considerations for monitoring fertility-preserving approaches in early-stage low-grade EC
Переглядів 1919 годин тому
Yukio Suzuki, MD, PhD, Columbia University Irving Medical Center, New York, NY, discusses key considerations for monitoring fertility-preserving approaches in early-stage low-grade endometrial cancer. This interview took place during the 2024 American Society of Clinical Oncology (ASCO) Meeting in Chicago, IL. These works are owned by Magdalen Medical Publishing (MMP) and are protected by copyr...
Phase II PATHWay: adjuvant pembrolizumab in patients with HNSC cancer at high risk for recurrence
Переглядів 5519 годин тому
Shloma Koyfman, MD, Cleveland Clinic, Cleveland, OH, discusses findings from the PATHWay trial (NCT02841748), evaluating pembrolizumab's adjuvant use in high-risk head/neck squamous cell carcinoma post-curative treatment. Pembrolizumab demonstrated superior progression-free survival (PFS) compared to placebo. Notably, PFS benefits extended to subgroups like salvage surgery recipients and those ...
Intra-treatment hypoxia directed major radiation de-escalation as definitive treatment for HPV+ OC
Переглядів 15019 годин тому
Shloma Koyfman, MD, Cleveland Clinic, Cleveland, OH, discusses the outcomes of a multi-center Phase II trial investigating hypoxia-directed de-escalated chemoradiotherapy without surgery for human papillomavirus associated oropharyngeal carcinoma (HPV OPC). With 150 eligible patients, de-escalation to 30Gy based on hypoxia status achieved notable toxicity reduction while maintaining a 2-year lo...
Phase I study of anti-HER2 CAR-engineered monocytes in HER2-overexpressing solid tumors
Переглядів 6119 годин тому
Yara Abdou, MD, UNC School of Medicine, Chapel Hill, NC, discusses the innovative advances in CAR-Mono cell therapy. Dr Abdou highlights the development of CT-0525, a next-generation anti-HER2 CAR-Mono cell therapy designed to enhance tumor targeting and reduce manufacturing time compared to earlier CAR-M therapies. CT-0525 utilizes autologous CD14 monocytes engineered with an Ad5f35 adenoviral...
Disparities in care of older adults of color with cancer
Переглядів 919 годин тому
Efrat Dotan, MD, Fox Chase Cancer Center, Philadelphia, PA, discusses the disparities faced by older adults of color with cancer. Dr Dotan emphasizes that these disparities are even more pronounced in older patients of color, necessitating a thorough evaluation at baseline. She advocates for the use of comprehensive geriatric assessments and an understanding of social determinants of health to ...
Challenges in managing vulnerable older adults with newly diagnosed metastatic PDAC
Переглядів 1319 годин тому
Efrat Dotan, MD, Fox Chase Cancer Center, Philadelphia, PA, discusses the unique challenges faced by older adults with pancreatic cancer, a condition often diagnosed at a median age of 70. Dr Dotan highlights that these patients frequently contend with multiple comorbidities, functional impairments, nutritional issues, and cognitive challenges, all of which impact their ability to tolerate and ...
Phase II GIANT trial insights: managing older adults with metastatic pancreatic cancer
Переглядів 1419 годин тому
Efrat Dotan, MD, Fox Chase Cancer Center, Philadelphia, PA, discusses the implications of the Phase II GIANT trial (NCT04233866) for managing vulnerable older adults with newly diagnosed metastatic pancreatic ductal adenocarcinoma (mPDAC). The GIANT trial is notable for including real-world, vulnerable patients aged 70 and older, providing valuable insights into treatment outcomes for this grou...
AI advancements at ASCO 2024: transformative impact on cancer diagnosis, treatment, & research
Переглядів 2919 годин тому
AI advancements at ASCO 2024: transformative impact on cancer diagnosis, treatment, & research
Key melanoma highlights from ASCO 2024, including RELATIVITY-048 and NADINA trials
Переглядів 2619 годин тому
Key melanoma highlights from ASCO 2024, including RELATIVITY-048 and NADINA trials
Advancements in prostate cancer therapies from ASCO 2024
Переглядів 5719 годин тому
Advancements in prostate cancer therapies from ASCO 2024
Impact of CDK4/6 inhibitors on HR-positive, HER2-negative advanced breast cancer
Переглядів 6519 годин тому
Impact of CDK4/6 inhibitors on HR-positive, HER2-negative advanced breast cancer
Key takeaways from ASCO 2024: advances in kidney cancer biomarkers and neoadjuvant therapy
Переглядів 9121 годину тому
Key takeaways from ASCO 2024: advances in kidney cancer biomarkers and neoadjuvant therapy
Highlights in lung cancer from ASCO 2024
Переглядів 5921 годину тому
Highlights in lung cancer from ASCO 2024
Opportunities in MRD detection and intervention in multiple solid tumors
Переглядів 6714 днів тому
Opportunities in MRD detection and intervention in multiple solid tumors
The future of ADCs in effectively treating colorectal cancer
Переглядів 49414 днів тому
The future of ADCs in effectively treating colorectal cancer
PROCEADE-CRC-01: an anti-CEACAM5 ADC for metastatic colorectal cancer
Переглядів 11514 днів тому
PROCEADE-CRC-01: an anti-CEACAM5 ADC for metastatic colorectal cancer
Targeting genetic variants in mCRPC to improve survival outcomes
Переглядів 5014 днів тому
Targeting genetic variants in mCRPC to improve survival outcomes
ctDNA models for predicting survival outcomes in mCRPC
Переглядів 6714 днів тому
ctDNA models for predicting survival outcomes in mCRPC
Promising survival outcomes in glioblastoma with autologous gamma-delta T cells
Переглядів 3814 днів тому
Promising survival outcomes in glioblastoma with autologous gamma-delta T cells
Advancing glioma treatment using autologous gamma-delta T cells
Переглядів 2514 днів тому
Advancing glioma treatment using autologous gamma-delta T cells
Gene-modified autologous gamma-delta T cells in glioblastoma multiforme
Переглядів 4214 днів тому
Gene-modified autologous gamma-delta T cells in glioblastoma multiforme
Implications of immunotherapy for personalized colorectal cancer treatments
Переглядів 1914 днів тому
Implications of immunotherapy for personalized colorectal cancer treatments

КОМЕНТАРІ

  • @godschild3640
    @godschild3640 17 днів тому

    Please, we need to have some kind of anesthesia for needle biopsies because it is very very painful. They say it’s not painful, but it is abusive.

  • @katherine1121
    @katherine1121 3 місяці тому

    Moisturize!

  • @1Sunrose
    @1Sunrose 3 місяці тому

    Any update on this exercise for cancer ?

  • @Unabrazodayfor
    @Unabrazodayfor 4 місяці тому

    I was able to cure my bone cancer permanently using Dr. Obehi Herbal Home's herbal remedy on UA-cam❤

  • @erdem-dg6xq
    @erdem-dg6xq 4 місяці тому

    How long can we survive on fruits alone without drinking any liquids?

  • @luckspell
    @luckspell 5 місяців тому

    Aoh1996 dostarlimab

  • @lamamapanda9868
    @lamamapanda9868 7 місяців тому

    As a cancer patient what can we eat to help our gut?

  • @DBEN153662
    @DBEN153662 7 місяців тому

    they want to put me on some burning cream for 5 days 😮

  • @user-du5so9ur7b
    @user-du5so9ur7b 8 місяців тому

    All thanks to Dr obehi herbal home on UA-cam for helping me cure Bone cancer that almost took my life. Am totally cured 🤗🤗❤️❤

  • @thomasperry4825
    @thomasperry4825 8 місяців тому

    Emergency C with B vitamins Gummies made mine go away!!!

    • @jeremycox5003
      @jeremycox5003 4 місяці тому

      Any specific brand?

    • @thomasperry4825
      @thomasperry4825 4 місяці тому

      It came back and had to go to the doctor 😢

    • @BPMKEV
      @BPMKEV 18 днів тому

      ​@@thomasperry4825any update? I just got one and I'm kinda worried

  • @kelvin1007
    @kelvin1007 9 місяців тому

    Diarrhea or acne vs treating cancer…. Seems like a luxury problem

  • @Three-Chord-Trick
    @Three-Chord-Trick 11 місяців тому

    I don't go in for the pseudo-Freudian pop psychology thing; but I can't help feeling that you seek comfort in science because you can't find a man who can satisfy you in the bedroom. 😮

  • @originalandrewmark
    @originalandrewmark Рік тому

    What risk? According to Doctors whose prescience precludes observable facts, DEATH is here and the patient, according to you, WILL die in hours So again, what risk?

  • @martam518
    @martam518 Рік тому

    What are all side effects of this drug? My friend had horrible side effects. Way way way worse than from.regular chemo she was getting 6 months before . She tolerater previous treatment very well. She had not diahreaa but constipation and vomiting 24 hiurs. Could not drink even water as she would vomit water right back. She was all shaky, her hands were doing weird stuff..huge headake. Pain level 10 out of 10. Its still chemo. You guys should tell people all possible side effects expected and a duration.Stop lieying to people that is just diarrhea. God is watching your action. Be bless and honest.

  • @rigardo911
    @rigardo911 Рік тому

    He was one of my the best teacher I had .

  • @VJOncology
    @VJOncology Рік тому

    Watch more in lung cancer here: www.vjoncology.com/subject/lung-cancer/?lungchannel

  • @VJOncology
    @VJOncology Рік тому

    Stay up to date with the latest in GU cancer here: www.vjoncology.com/subject/genitourinary-cancer/?GUchannel

  • @VJOncology
    @VJOncology Рік тому

    Stay up to date with the latest news in radiotherapy in oncology here: www.vjoncology.com/field/radiotherapy/?radiotherapytopic

  • @VJOncology
    @VJOncology Рік тому

    Stay up to date with the latest news in GU cancers here: VJOncology.com/subject/genitourinary-cancer/?GUchannel

  • @VJOncology
    @VJOncology Рік тому

    Stay up to date with the latest news in immunotherapy here: VJOncology.com/subject/genitourinary-cancer/?GUchannel

  • @VJOncology
    @VJOncology Рік тому

    Stay up to date with the latest news in immuno-oncology here: www.vjoncology.com/field/immuno-oncology/?immunoonctopic

  • @VJOncology
    @VJOncology Рік тому

    Stay up to date with the latest news in GU cancers here: VJOncology.com/subject/genitourinary-cancer/?GUchannel

  • @VJOncology
    @VJOncology Рік тому

    Check out the latest in prostate cancer screening and more on our website: www.vjoncology.com/field/screening/?screeningtopic

  • @VJOncology
    @VJOncology Рік тому

    Check out the latest in gynecologic cancers on our website: www.vjoncology.com/subject/gynecological-cancer/?gynechannel

  • @VJOncology
    @VJOncology Рік тому

    For more immunotherapy updates check out VJOncology - www.vjoncology.com/field/immuno-oncology/?immunoonctopicl !

  • @VJOncology
    @VJOncology Рік тому

    Stay up to date with the latest in immunotherapy here: www.vjoncology.com/field/immuno-oncology/?immunoonctopic

  • @VJOncology
    @VJOncology Рік тому

    Stay up to date with the latest news in GU cancers here: VJOncology.com/subject/genitourinary-cancer/?GUchannel

  • @VJOncology
    @VJOncology Рік тому

    Stay up to date with the latest news in GU cancers here: VJOncology.com/subject/genitourinary-cancer/?GUchannel

  • @VJOncology
    @VJOncology Рік тому

    Learn more about Gynecological Cancers here: VJOncology.com/subject/gynecological-cancer/?gynechannel

  • @VJOncology
    @VJOncology Рік тому

    Watch the latest news in Gynecological Cancers here: VJOncology.com/subject/gynecological-cancer/?gynechannel

  • @VJOncology
    @VJOncology Рік тому

    Stay up to date with the latest news in GU cancers here: VJOncology.com/subject/genitourinary-cancer/?GUchannel

  • @VJOncology
    @VJOncology Рік тому

    For more Lung Cancer updates check out VJOncology - VJOncology.com/subject/lung-cancer/?lungchannel !

  • @VJOncology
    @VJOncology Рік тому

    For more on Genitourinary Cancers click here: VJOncology.com/subject/genitourinary-cancer/?GUchannel

  • @VJOncology
    @VJOncology Рік тому

    Checkout the latest in GU cancers on our website: www.vjoncology.com/subject/genitourinary-cancer/?GUchannel

  • @VJOncology
    @VJOncology Рік тому

    Check out the latest in gynecologic cancers on our website: www.vjoncology.com/subject/gynecological-cancer/?gynechannel

  • @VJOncology
    @VJOncology Рік тому

    Check out the latest in GI cancers on our website: www.vjoncology.com/subject/gastrointestinal-cancer/?gichannel

  • @kevywilliams3304
    @kevywilliams3304 Рік тому

    IDIOTS !!!!!!!! THE MICROBIOME BEING CORRUPTED BY CORRUPT FOOD…. IS THE ENTIRE CAUSE OF DISEASE AND CANCER!!!!

  • @antoniothomas9830
    @antoniothomas9830 2 роки тому

    I am happy to share to the public and to let everyone know about #drodia on UA-cam who has the most effective medicines for Herpes Virus.☺

  • @antoniothomas9830
    @antoniothomas9830 2 роки тому

    I am happy to share to the public and to let everyone know about #drodia on UA-cam who has the most effective medicines for Herpes Virus.☺

  • @dprince5271
    @dprince5271 2 роки тому

    I highly recommend Dr. Osaka on UA-cam channel, who helped me in getting rid of my herpes an my wife from liver cancer, It was Amazing seeing the both of us free from the deadly diseases with the help of Dr. Osaka natural herbal remedy, I'm forever grateful Doctor.

  • @lailamya8360
    @lailamya8360 3 роки тому

    Drakahomen on UA-cam cure my herpes virus with his amazing herbal medicine contact him on WhatsApp +2348051567735 medicine.drakahomen@gmail.com,

  • @sarahashelford7113
    @sarahashelford7113 3 роки тому

    This is a very powerful video for undergraduate and newly-qualified nurses, as well as more experienced nurses all areas of practice

  • @dr.komalbehl5147
    @dr.komalbehl5147 3 роки тому

    drkomalbehl.blogspot.com/2021/03/23-03-21-mehul-vyas-miracle-man.html Story of real life hero

  • @lx1714
    @lx1714 3 роки тому

    Thank you for this helpful video

  • @marketingladseo
    @marketingladseo 3 роки тому

    Great Video! Also, listen to this podcast -How a Leader Should Deal From Mental Exhaustion. ua-cam.com/video/3hrrJmpvNVU/v-deo.html

  • @cristinacrist6681
    @cristinacrist6681 3 роки тому

    Being suffering from genital cancer for over 3 years and today I tested negative after using Dralamale036@gmail.com on you tube herbal treatment....

  • @katherineobrien5971
    @katherineobrien5971 3 роки тому

    I was diagnosed with metastatic breast cancer in 2019 at the age of 43. Although 90 percent of the 155,000 people in the United States currently living with metastatic breast cancer were previously treated for early stage breast cancer, that wasn’t the case for me. I was metastatic from my first diagnosis. Getting my head around this diagnosis was challenging. So that gave me options to go online for my research on UA-cam until I came across doctor Harvey herbal world who cured me with is his natural herbs and roots called PROPOLIS LECTIHIN CAPSULE I contacted him on WhatsApp that day and he answered me and I told him about my cancer diagnosis,so he told me about his herbal products PROPOLIS LECTIHIN CAPSULE so I got the herbal products and start to administer it according to the prescription so within two weeks behold I was feeling better and stronger, so I gave myself time till the third week then went for text with my local doctor and nothing was absolutely there and was cured of cancer. Now I’m totally cancer free.. All thanks to Dr Harvey There’s no need for chemotherapy, radiation and surgery rather contact Dr. Harvey herbal world on WhatsApp: + 1 (475) 522 1289 Email: drharveyphytotherapy07@gmail.com.

  • @drotoi9332
    @drotoi9332 3 роки тому

    I am very glad to be sharing with everyone here for the marvelous work @dr_osas_ done for my life, i was diagnosed of Herpes virus and ever since i have been very unhappy, i so down broken everyday, until one day when i came across a shocking testimony about how @dr_osas_ cured someone of her Herpes virus, without wasting much time i link him up immediately on @dr_osas_ and his WhatsApp : +2349078898053 If You what to cure your disease kindly contact him okay Thanks to @Dr_osas_ Email address: drosasherbalhome7@gmail.com

  • @mariej.thomas8243
    @mariej.thomas8243 3 роки тому

    I discovered I had breast cancer by accident. I had just given birth to my 2nd child when I noticed a small lump on my left breast. Milk was coming out, but I didn't think anything of it because I was breast feeding. Well while carrying the baby I noticed a lump and some pain. I immediately went to the radiologist where she told me straight out that she believed I should see a doctor ASAP because I might have breast cancer. I was so glad she told me so directly; otherwise I probably would have overlooked the milky discharge from my nipple as milk. I went through Chemotherapy, Double Mastectomy, and reconstruction still after some few years the symptoms still persists. It was a long journey, and at times I wanted to give up, but I kept the fight for my two kids that I have to raise and kept searching for help until a friend of mine who was a survivor of Stage 4 Breast cancer introduced me to Dr Harvey who cured her using his natural herbal remedy. I contacted him by email, he got back to me and told me about the solution to my illness and how to go about it, i did as he instructed and about the three days i got the cure Which he prepared and sent to me through DHL courier service, i administered the herbal medicine as he instructed me and that's how i was cured of Breast Cancer. All thanks to the superb healing herbs of Dr Harvey Contact Dr Harvey now via (drharveyphytotherapy@yahoo.com) Whatsapp: +1 (971) 666-3103

  • @christyjhoward5557
    @christyjhoward5557 3 роки тому

    I am a 51 year old single mom of 3 children. I was diagnosed with lung cancer in 2018, I have been through 38 radiation treatments as well as chemo treatments. While doing the radiation treatments, the pain in the spine had just about gone away. Now that the treatments have stopped the pain in my spine is worse than before. An MRI was done and the tumor still isn’t shrinking and it seems to be worse. I owe all thanks to my friend Helen who introduced me to Dr Harvey a herbal doctor that saved my life and helped me cure my lung cancer with his wonderful herbal remedy and I will urge everyone suffering from this dreadful illness to also contact him for the cure. You can contact him via (drharveyphytotherapy@yahoo.com) Whatsapp: +1 (971) 666-3103

    • @pixieizzy5431
      @pixieizzy5431 3 роки тому

      Is this legit?I'm a suffering with symptoms of lung cancer and this is my only hope